![]() ![]() Tell your doctor if you regularly drink grapefruit juice. When used together with higher doses of simvastatin, these medicines may increase your risk of muscle injury and could result in kidney problems. Do not use more than 20 mg per day of simvastatin together with amiodarone (Cordarone®), amlodipine (Norvasc®), lomitapide (Juxtapid™), or ranolazine (Ranexa®). If you are taking diltiazem (Cardizem®), dronedarone (Multaq®), or verapamil (Calan®, Isoptin®, Verelan®) together with simvastatin, your simvastatin dose should not be higher than 10 milligrams (mg) per day, unless otherwise directed by your doctor. Carefully follow your doctor's orders about any special diet. In addition to this medicine, your doctor may change your diet to one that is low in fat, sugar, and cholesterol. Use a marked measuring spoon, oral syringe, or medicine cup to measure the right dose. Shake the oral suspension well for at least 20 seconds before using it. ![]() Take this medicine on the evening, on an empty stomach. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Take this medicine only as directed by your doctor. Liver enzymes elevated-Should not be used in patients with these conditions. Hypercholesterolemia (high cholesterol in the blood), familial homozygous-Dosage may be adjusted in this condition. Trauma-Patients with these conditions may be at risk for muscle or kidney problems. May cause side effects to become worse.Įpilepsy (seizures), not well-controlled or Liver disease, history of-Use with caution. Hypothyroidism (an underactive thyroid), not well-controlled or Make sure you tell your doctor if you have any other medical problems, especially: The presence of other medical problems may affect the use of this medicine. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using alcohol or tobacco with certain medicines may also cause interactions to occur. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Ĭertain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is not recommended. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Drug InteractionsĪlthough certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine. Studies in women breastfeeding have demonstrated harmful infant effects. However, elderly patients are more likely to have age-related liver, kidney, heart, or muscle problems (eg, myopathy and rhabdomyolysis), which may require caution in patients receiving simvastatin. GeriatricĪppropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of simvastatin in the elderly. Teenage girls taking simvastatin should be counseled on appropriate birth control methods to prevent pregnancy. Safety and efficacy have not been established. Appropriate studies have not been performed on the relationship of age to the effects of simvastatin in children younger than 10 years of age. ![]()
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